My Internet connection went down last night at 9pm. I confess that I briefly wondered if it was related to Conficker. Then I rebooted my router and was back up again.
It doesn't appear that Conficker has done anything particularly noticeable (yet?). No surprise there. I did come up with what I thought was a feasible outcome that would have a significant impact – or at least a unique one:
A Jim Jones-style mass suicide where Conficker (the Kool-Aid) downloaded code to kill the machine it was on. I think 10 million "dead" machines might have made an impact, though I am not positive about that.