I am fascinated with my own complacency on this topic. I read a lot of blogs and a lot of trade rags, but I skip past all of the Storm worm headlines… I guess I’ll have to dive deeper since someone somewhere indicated that it is the most "successful" worm ever or something…
Is there a large enterprise in the world that is (or was) significantly impacted by this thing?
I think there is a growing gap between consumer and enterprise security that might explain this phenomenon… (or a growing gap between my ears? 
).
It’s probably safe to say that all ISPs have been affected by this. You know the controversy over Comcast limiting BitTorrent traffic? I’m fairly certain it’s related to their efforts to quiet the Storm (though it’s being spun as a net neutrality thing). The spam volume certainly can be correlated directly to this worm, and that accounts for millions, if not billions, in expenses. Given that we’re talking tens of thousands of compromised hosts, there are probably several ways in which it has impacted Internet life across the board, whether it be enterprise or consumer space.